| F2 | Rename the selected node, file, or folder |
| F3 | Disable selected nodes |
| F4 | Enable selected nodes |
| Delete | Delete selected nodes |
| Shift+Arrow Left | Collapse a branch in the model tree |
| Shift+Arrow Right | Expand a branch in the model tree |
| Arrow Up | Move to the node above in the model tree |
| Arrow Down | Move to the node below in the model tree |
| Alt+Arrow Left | Move to the previously selected node in the model tree |
| Alt+Arrow Right | Move to the next selected node in the model tree |
| Ctrl+A | Select all domains, boundaries, edges, or points; select all cells in a table |
| Ctrl+C | Copy text in fields |
| Ctrl+D | Clear the selection of domains, boundaries, edges, or points |
| Ctrl+F | Find a search string |
| Ctrl+N | New model |
| Ctrl+O | Open a model file |
| Ctrl+P | Print the contents of the plot window |
| Ctrl+S | Save a model file |
| Ctrl+V | Paste copied text |
| Ctrl+Y | Redo the last undone operation |
| Ctrl+Z | Undo the last operation |
| Ctrl+Arrow Up | Move a definitions node, geometry node, physics node (except default nodes), material node, mesh node, study step node, or results node up one step |
| Ctrl+Arrow Down | Move a definitions node, geometry node, physics node (except default nodes), material node, mesh node, study step node, or results node down one step |
| Ctrl+Tab | Switch focus to the next window on the desktop |
| Ctrl+Shift+Tab | Switch focus to the previous window on the desktop |
| Ctrl+Alt+A | Go to Application Builder |
| Ctrl+Alt+M | Go to Model Builder |
| Ctrl+Alt+Arrow Left | Switch focus to the Model Builder window |
| Ctrl+Alt+Arrow Right | Switch focus to the Settings window |
| Ctrl+Alt+Arrow Up | Switch focus to the previous section in the Settings window |
| Ctrl+Alt+Arrow Down | Switch focus to the next section in the Settings window |
| Shift+F10 | Open the context menu |
| Ctrl+Space | Open list of predefined quantities for insertion in Expression fields for plotting and results evaluation |