| Backspace | Move to parent folder |
| Number Pad + | Group select |
| Number Pad - | Group deselect |
| Number Pad * | Invert selection |
| Tab | Moves focus between tabs (documents) in the active pane group |
| Delete | Delete selected object |
| Esc | Cancel transfer |
| F1 | Help |
| F2 | Rename |
| F3 | Find next |
| F4 | Switch between Site Manager and Local Drives tabs |
| F5 | Refresh active pane |
| F8 | Display folder information |
| F9 | Cancel transfer |
| F10 | Switch between Log pane and Queue pane |
| F11 | Folder comparison options |
| F12 | Hide or display individual log window |
| Alt+Enter | Folder, file, or Site properties |
| Alt+Arrow Up | Move to parent folder |
| Alt+Arrow Down | Select drop-down arrow for active pane |
| Alt+Arrow Right | Show bookmark drop-down for remote pane |
| Alt+Arrow Left | Show bookmark drop-down for local pane |
| Alt+F7 | Display Global Options dialog box |
| Alt+0 | Toggle show Site Manager /Local Pane view |
| Alt+1 | Toggle show Queue /Log Pane |
| Alt+2 | Hide or display individual log window (same as F12) |
| Alt+3 | Toggle show status bar |
| Alt+Q | Exit |
| Command+A | Select All |
| Command+B | Bold Font (when in HTML editor), Browse offline (when a Site is selected in Site Manager pane) |
| Command+C | Copy |
| Command+D | Change remote folder |
| Command+E | Execute selected file |
| Command+F | Find |
| Command+H | Launch internal HTML editor |
| Command+I | Italic Font (when in HTML editor mode) |
| Command+J | Launch Connection wizard |
| Command+L | Filter |
| Command+M | Make new folder |
| Command+N | Opens the Site Properties dialog box in which you can define a new Site. |
| Command+O | Opens file on your computer. |
| Command+P | Print (when in HTML editor mode) |
| Command+Q | Add current path as new bookmark |
| Command+R | Reconnect to last connected Site |
| Command+T | Connects to Site selected in the Site Manager |
| Command+S | Save open document (HTML editor mode) |
| Command+U | Connect to URL or underline when HTML editor is active. |
| Command+V | Paste |
| Command+W | Opens selected file for editing |
| Command+X | Cut |
| Command+Y | Redo (When in HTML editor mode) |
| Command+Z | Undo (When in HTML editor mode) |
| Command+F4 | Close active pane |
| Command+F8 | Open/close the Quick Connect toolbar |
| Command+F9 | Folder Monitor Tool |
| Command+F10 | Folder Backup Tool |
| Command+F11 | Folder Synchronize Tool |
| Command+~ | Move focus between left, right and bottom panes |
| Command+Page Down | Download |
| Command+Page Up | Upload |
| Command+Tab | Move focus right to left among open connections and documents |
| Command+Enter | Edit selected file (also creates a line-break when in the integrated editor's Find/Replace utility) |
| Command+Alt+T | Toggles Thumbnail view |
| Command+Shift+A | Add anchor (when in HTML editor mode) |
| Command+Shift+B | Change item queue order (place at bottom) |
| Command+Shift+C | Add comment (when in HTML editor mode) |
| Command+Shift+D | Change item queue order (move down one) |
| Command+Shift+I | Font dialog (when in HTML editor mode), Input RAW FTP command when in CuteFTP mode |
| Command+Shift+L | Clear entire log |
| Command+Shift+T | Change item queue order (move to top) |
| Command+Shift+U | Change item queue order (move up one) |
| Shift+F4 | Disconnect |